The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 1994
Filed:
Apr. 15, 1992
Applicant:
Inventor:
Ching-Shih Chen, Wakefield, RI (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P / ;
U.S. Cl.
CPC ...
435280 ;
Abstract
A computer modeling approach is taken to delineate the structural requirements of substrate molecules for biocatalytic turnover and enantioselective discrimination. This leads to an efficient enzymatic preparation of optically active propranolol. The acyl-sustituents on the alcohol and the secondary amine of propranolol play crucial roles in controlling the catalysis and enantiospecificity, respectively, of the enzymatic hydrolysis.