Company Filing History:
Years Active: 2010-2012
Title: Innovations of Chi-nung Hsiao in Pharmaceutical Chemistry
Introduction
Chi-nung Hsiao is a notable inventor based in Taipei County, Taiwan. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the synthesis of complex compounds. With a total of 2 patents, his work has garnered attention for its innovative approaches to drug synthesis.
Latest Patents
One of Chi-nung Hsiao's latest patents is titled "One pot synthesis of tetrazole derivatives of rapamycin." This invention presents a single-step, one-pot process to obtain zotarolimus and other rapamycin derivatives on a large scale. The method improves upon currently available synthesis schemes, making it more efficient. In this process, dried rapamycin is dissolved in isopropylacetate (IPAc), and after cooling, 2,6-Lutidine is added. Triflic anhydride is then slowly introduced at -30°C. Following filtration to remove salts, tetrazole and diisopropylethylamine (DIEA) are added to the triflate solution. The product is concentrated and purified through a silica gel column using THF/heptane as an eluant. The fractions containing the product are collected, concentrated, and further purified using an acetone/heptane column. The final product undergoes additional treatments to ensure stability and purity.
Career Highlights
Chi-nung Hsiao is currently associated with Abbott Laboratories Corporation, where he continues to innovate in the field of pharmaceutical development. His work has not only advanced the synthesis of important compounds but has also contributed to the broader field of medicinal chemistry.
Collaborations
Throughout his career, Chi-nung Hsiao has collaborated with esteemed colleagues, including Madhup K Dhaon and Subhash R Patel. These collaborations have further enriched his research and development efforts.
Conclusion
Chi-nung Hsiao's contributions to pharmaceutical chemistry, particularly through his innovative patent on the synthesis of tetrazole derivatives, highlight his role as a significant inventor in the field. His work continues to influence the development of new therapeutic agents.