This inventor holds 6 USPTO granted patents and 3 published patent applications and 1 EPO patent. Top assignees: Seasons Biotechnology (Taizhou) Co., Ltd., Seasons Biotechnology Co., Ltd.. Active years: 2018-2023.
Location History:
- Shanghai, CN (2018 - 2019)
- Taizhou, CN (2020 - 2023)
Company Filing History:
5 out of 5 
1 out of 1 Years Active: 2018-2023
Title: Chi Ma: Innovator in Chemical Synthesis
Introduction
Chi Ma is a prominent inventor based in Shanghai, China. He has made significant contributions to the field of chemical synthesis, particularly in drug preparation. With a total of six patents to his name, Chi Ma has established himself as a key figure in the pharmaceutical industry.
Latest Patents
One of Chi Ma's latest patents is a method for preparing Macitentan and its intermediate compound. This invention relates to the technical field of chemical synthesis of drugs. The preparation method involves adding a THF solution containing compound II and 5-bromo-2-chloropyrimidine slowly into a THF solution containing a base. Alternatively, both solutions can be added simultaneously into the base solution to react and obtain Macitentan. The bases used in this process include sodium hydride, potassium hydride, lithium hydride, or lithium bis(trimethylsilyl)amide. The selectivity of this preparation method is notably high, making it suitable for industrial production. The resulting product, Macitentan, exhibits excellent quality and high yield. Additionally, the intermediate compound II also demonstrates good quality, with an HPLC purity of up to 99.0%. The content of impurity A is less than 0.20%, and the content of impurity B is less than 0.25%.
Career Highlights
Chi Ma has worked with notable companies in the biotechnology sector, including Seasons Biotechnology (Taizhou) Co., Ltd. and Seasons Biotechnology Co., Ltd. His work in these organizations has contributed to advancements in drug synthesis and development.
Collaborations
Chi Ma has collaborated with esteemed colleagues such as Qiang Jia and Fanghui Tang. These partnerships have fostered innovation and progress in their shared field of expertise.
Conclusion
Chi Ma is a distinguished inventor whose work in chemical synthesis has led to significant advancements in drug preparation. His innovative methods and collaborations continue to impact the pharmaceutical industry positively.