Cheryl F Scott

Title: Cheryl F Scott: Innovator in Kininogen Assays

Introduction

Cheryl F Scott is a notable inventor based in Bensalem, PA (US). She has made significant contributions to the field of biomedical research, particularly in the development of assays for high molecular weight kininogen.

Latest Patents

Cheryl F Scott holds a patent for a "High molecular weight kininogen assay." This innovative assay provides a method for determining the functional high molecular weight kininogen in plasma. The process involves treating a plasma sample to inactivate plasma protease inhibitors and kallikrein, followed by neutralization and dilution. Exogenous factor XIIa and factor XI are added to create a reaction mixture, which is incubated with a contact-activating surface. The concentrations of factor XIIa and factor XI are carefully selected to ensure that the concentration of functional high molecular weight kininogen is rate-limiting in the activation of factor XI by factor XIIa. The amount of factor XIa generated is directly proportional to the concentration of functional high molecular weight kininogen in the sample.

Career Highlights

Cheryl F Scott is affiliated with Temple University, where she continues her research and development efforts. Her work has been instrumental in advancing the understanding of kininogen and its implications in various medical conditions.

Collaborations

Cheryl collaborates with Robert W Colman, who is also involved in research related to kininogen and its assays. Their partnership has contributed to the advancement of knowledge in this specialized field.

Conclusion

Cheryl F Scott's innovative work in the development of kininogen assays highlights her significant contributions to biomedical research. Her patent and ongoing research efforts at Temple University underscore her role as a leading inventor in this important area of study.