Company Filing History:
2 out of 611 
1 out of 1 Years Active: 2022-2024
Title: Innovations of Chenxu Zhu in DNA Modification and Sequencing
Introduction
Chenxu Zhu is a prominent inventor based in Beijing, China, known for his significant contributions to the field of DNA modification and sequencing. With a total of two patents to his name, Zhu has made remarkable advancements that have implications in genetic research and biotechnology.
Latest Patents
Zhu's latest patents include "Tale RVD specifically recognizing DNA base modified by methylation and application thereof" and "Method for marking 5-formyl cytosine and use thereof in single base resolution sequencing." The first patent identifies RVDs with recognition preferences for 5mC, 5hmC, and 6 mA, which can be utilized for methylation-dependent gene activation, efficient genome editing, and targeted detection of 5hmC. This invention provides an isolated DNA binding polypeptide containing TALEs, a fusion protein, a polynucleotide, a vector, and a host cell, facilitating the detection of methylated bases in target gene sequences. The second patent discloses a method for marking 5-formyl cytosine, which involves preparing a DNA or RNA sample and mixing it with a buffer solution and a specific compound to achieve marking. This method can be implemented at a single-cell level, allowing for sequencing at single-base resolution.
Career Highlights
Chenxu Zhu has worked at notable institutions, including Peking University and Edigene Inc. His work has significantly impacted the field of genetic research, particularly in understanding epigenetic modifications and their applications in biotechnology.
Collaborations
Zhu has collaborated with esteemed colleagues such as Chengqi Yi and Wensheng Wei, contributing to the advancement of research in DNA modification and sequencing technologies.
Conclusion
Chenxu Zhu's innovative work in DNA modification and sequencing has paved the way for new methodologies in genetic research. His patents reflect a deep understanding of epigenetic mechanisms and their potential applications in various scientific fields.