Company Filing History:
Years Active: 2006
Title: Innovations by Chau M Du in Membrane Permeability Measurement
Introduction
Chau M Du is an accomplished inventor based in Allston, MA (US). He has made significant contributions to the field of pharmaceutical and biotechnological research through his innovative inventions. His work focuses on improving methods for measuring membrane permeability of chemical compounds, which is crucial for drug development and other applications.
Latest Patents
Chau M Du holds a patent for a "Method and apparatus for improving in vitro measurement of membrane permeability of chemical compounds." This invention enhances the PAMPA (parallel artificial membrane permeability assay) method used in pharmaceutical, biotechnological, and agrochemical research and development. The new high-throughput method and apparatus address the shortcomings of prior art by incorporating sensitivity and speed-enhancing reagents. The phospholipid membranes utilized in this method consist of 10–74% wt/vol soybean lecithin extract dissolved in dodecane. Concentrations are measured using direct UV spectroscopy. To minimize membrane retention, surfactants, cyclodextrins, or water-soluble lipophilic polymers with low UV absorption are employed in the acceptor compartment of the permeation cells, creating an artificial sink state. Additionally, a pH gradient established between donor and acceptor solutions creates a secondary sink state. This 'double-sink' condition enables successful modeling of passive-diffusion transport of molecules. By accelerating the transport of certain molecules, this method shortens measurement time and increases assay throughput. A new permeability equation has been developed to account for the 'double-sink' condition as well as membrane retention.
Career Highlights
Chau M Du is currently associated with Pion Inc., where he continues to advance research in membrane permeability measurement. His innovative approach has positioned him as a key figure in the field, contributing to the development of more efficient and effective testing methods.
Collaborations
Chau has collaborated with notable professionals in his field, including Alex Avdeef and Per E Nielsen. These collaborations have further enriched his research and contributed to the advancement of methodologies in membrane permeability measurement.
Conclusion
Chau M Du's innovative work in improving membrane permeability measurement methods has made a significant impact on pharmaceutical and biotechnological research. His contributions continue to enhance the efficiency and effectiveness of drug development processes.