Charlotte J Sumner

Title: Charlotte J Sumner: Innovator in SMN Expression Modulation

Introduction

Charlotte J Sumner is a prominent inventor based in Baltimore, MD (US). She has made significant contributions to the field of molecular biology, particularly in the modulation of SMN (Survival Motor Neuron) expression. With a total of 2 patents to her name, her work has the potential to impact therapeutic approaches for various diseases.

Latest Patents

Charlotte's latest patents focus on innovative methods and compounds for modulating SMN expression. One patent describes combinations for the modulation of SMN expression, where certain embodiments are directed to methods and compounds for modulating the expression of SMN. In these embodiments, at least two compounds are utilized: a first compound for inhibiting SMN-NAT and increasing the expression of SMN, and a second compound for modulating the splicing of SMN. These methods and compounds are particularly useful for increasing the expression of exon 7 containing SMN mRNA in cells and animals. Another patent emphasizes the modulation of SMN expression, detailing methods and compounds for inhibiting SMN-NAT, the natural antisense transcript of SMN. Such innovations are crucial for enhancing SMN expression in cells and animals.

Career Highlights

Throughout her career, Charlotte has worked with notable organizations, including Ionis Pharmaceuticals, Inc. and The Johns Hopkins University. Her research and inventions have garnered attention in the scientific community, showcasing her expertise in the field.

Collaborations

Charlotte has collaborated with esteemed colleagues such as Frank Rigo and C Frank Bennett, further enhancing her contributions to the field of molecular biology.

Conclusion

Charlotte J Sumner is a trailblazer in the modulation of SMN expression, with her patents paving the way for future advancements in therapeutic strategies. Her work exemplifies the impact of innovative research in addressing critical health challenges.