Charles L Hofacre

Title: The Innovations of Charles L. Hofacre

Introduction

Charles L. Hofacre is a notable inventor based in Monroe, NC (US). He has made significant contributions to the field of veterinary medicine, particularly in the development of vaccines. His work has had a profound impact on the protection of livestock, especially turkeys, against infectious diseases.

Latest Patents

Hofacre holds a patent for a Pasteurella multocida vaccine. This vaccine was developed through the mutogenesis of the Clemson University (CU) vaccine strain of P. multocida using N-methyl-N-nitro-N-nitrosoguanidine. The result was temperature-sensitive (TS) mutants that could grow at 37 degrees Celsius but not at 42 degrees Celsius. Two specific mutants, PM#1 and PM#3, were identified as providing turkeys with a level of protection against a virulent serotype 3 P. multocida strain (P-1059) that was comparable to the protection offered by the CU strain.

Intravenous (IV) inoculation studies demonstrated that PM#1 and PM#3 resulted in lower mortality and lameness compared to the CU strain. Histopathological evaluations of spleens at various time points post-IV inoculation revealed that the CU strain induced twice as much splenic necrosis as either PM#1 or PM#3.

Career Highlights

Hofacre's career has been marked by his dedication to research and innovation in veterinary science. He is affiliated with the University of Georgia Research Foundation, Inc., where he continues to contribute to advancements in animal health.

Collaborations

One of Hofacre's notable collaborators is John R. Glisson. Their partnership has fostered advancements in vaccine development and veterinary research.

Conclusion

Charles L. Hofacre's work in developing the Pasteurella multocida vaccine exemplifies his commitment to improving animal health. His innovations have provided significant benefits to the poultry industry, ensuring better protection for livestock against infectious diseases.