Charles A Signorino

Title: Innovation in Tablet Coating: The Contributions of Charles A. Signorino

Introduction

Charles A. Signorino, a renowned inventor based in King of Prussia, Pennsylvania, has made significant contributions to the field of tablet and capsule coating. With a portfolio of 8 patents, he has dedicated his career to developing innovative solutions that enhance the pharmaceutical industry.

Latest Patents

Among his latest patents, two stand out for their innovative approaches to dye compositions and film coating methods. The first patent involves improved dye compositions for coating tablets, utilizing a stable, aqueous suspension that contains a water-soluble, nontoxic dye along with an opacifying agent such as titanium dioxide or iron oxide. The inclusion of an immobilizing agent, specifically a nontoxic metal salt, ensures the dye remains fixed in place, preventing migration during application. This formulation also accommodates a film-forming, water-soluble or water-dispersible edible polymer and a plasticizer, creating uniform and non-mottled coatings for tablets.

The second patent focuses on wet powder, edible film-forming compositions. These compositions are designed for coating tablets and capsules, consisting of powdered pigment particles combined with a film-forming, water-soluble or water-dispersible edible polymer. The incorporation of water (up to approximately 30% by weight) is performed atomized to precondition the polymer, enabling the production of smooth, stable coating suspensions free from fish eyes upon additional dilution.

Career Highlights

Throughout his professional journey, Charles A. Signorino has worked with notable companies, including Warner-Jenkinson Company, Inc. and Colorcon Incorporated. His innovative mindset and commitment to quality in pharmaceutical development have paved the way for advancements that benefit both manufacturers and end consumers.

Collaborations

Collaborating with esteemed individuals like Harry Meggos, Signorino has shared insights and exchanged ideas that have propelled his research and development efforts forward. These partnerships have played a crucial role in his success as an inventor.

Conclusion

Charles A. Signorino's contributions to tablet coating technologies highlight the significance of innovation in the pharmaceutical landscape. His patents not only improve the aesthetic quality of tablets and capsules but also enhance their functional performance, establishing him as a pivotal figure in the industry. Through his ongoing research and developmental work, Signorino continues to inspire future advancements in the field.