Charlene Marree Kahler

Title: Charlene Marree Kahler and Her Work on Neisseria Immunogenic Compositions.

Introduction

Charlene Marree Kahler is an inventor associated with Emory University in Decatur, Georgia. Her patent work concerns genetically modified strains of *Neisseria meningitidis* and their potential use in immunogenic compositions.

Latest Patents

Kahler is credited with 1 patent, titled “Neisseria Mutants, Lipooligosaccharides and Immunogenic Compositions.” The patent describes mutant *Neisseria meningitidis* strains that produce lipooligosaccharides (LOS) with structures that differ from wild-type LOS. It also covers mutant LOS molecules and immunogenic compositions containing truncated LOS molecules.

The disclosed strains include *N. meningitidis* NMB-559, which has an insertion mutation in a gene encoding an α-1,2-N-acetylglucosamine transferase, and NMB-469, which has an insertion mutation in the *nlaB* gene. The patent describes the *nlaB* protein as having significant sequence homology to an *Escherichia coli* gene associated with 1-acyl-sn-glycerol-3-phosphate acyltransferase.

Career Highlights

Kahler’s listed patent reflects research into bacterial surface molecules and the design of modified LOS structures for immunogenic compositions. The work focuses on genetic changes that can produce stable alterations in LOS.

Collaborations

David S. Stephens is identified as a coworker associated with Kahler’s work. The patent information provided connects the research to Emory University.

Conclusion

Charlene Marree Kahler’s patent documents research on genetically modified *Neisseria meningitidis* strains and altered lipooligosaccharides, highlighting her contribution to work on immunogenic compositions at Emory University.