This inventor holds 2 USPTO granted patents. Top assignee: Scripps Research Institute. Active years: 2021-2025.
Company Filing History:
Years Active: 2021-2025
Title: Innovations of Chao Li in Boronic Acid Chemistry
Introduction
Chao Li is a prominent inventor based in San Diego, CA, known for his significant contributions to the field of boronic acid chemistry. He holds 2 patents that focus on innovative methods for synthesizing boronic esters, which have important applications in medicinal chemistry.
Latest Patents
Li's latest patents revolve around Cu- and Ni-catalyzed decarboxylative borylation reactions. These inventions detail methods for converting carboxylic acid groups in compounds into corresponding boronic esters. This process involves the use of a redox active ester and treatment with a bis(pinacolato)diboron-alkyllithium complex, along with a ligand, a Ni(II) salt or a copper salt, and an Mg(II) salt. The resulting pinacolato boronate ester can be cleaved to yield a boronic acid. Furthermore, these patents also describe methods for preparing various compounds of medical value that contain boronic acid groups. Notable examples include atorvastatin boronic acid analogs, vancomycin aglycone boronic acid analogs, and boronic acid-containing elastase inhibitors such as mCBK319, mCBK320, mCBK323, and RPX-7009.
Career Highlights
Chao Li is affiliated with The Scripps Research Institute, where he conducts his research and development in boronic acid chemistry. His work has garnered attention for its potential impact on drug development and therapeutic applications.
Collaborations
Li collaborates with esteemed colleagues in his field, including Phil Baran and Jie Wang, who contribute to the innovative research environment at The Scripps Research Institute.
Conclusion
Chao Li's innovative work in boronic acid chemistry exemplifies the intersection of scientific research and practical applications in medicine. His patents reflect a commitment to advancing the field and improving therapeutic options.