South Plainfield, NJ, United States of America

Chan-Hwa Kuo


Average Co-Inventor Count = 2.6

ph-index = 3

Forward Citations = 59(Granted Patents)


Company Filing History:


Years Active: 1976-2000

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7 patents (USPTO):

Title: The Innovative Contributions of Chan-Hwa Kuo in Medical Chemistry

Introduction: Chan-Hwa Kuo, an accomplished inventor based in South Plainfield, NJ, is known for his significant contributions to the field of medicinal chemistry. With a portfolio of seven patents, Kuo's work primarily focuses on developing innovative compounds aimed at addressing critical health issues such as Type II diabetes and obesity.

Latest Patents: Among his notable patents is the invention of oxadiazole benzenesulfonamides, which serve as selective β3 adrenergic receptor agonists. These compounds demonstrate minimal β1 and β2 adrenergic receptor activity, making them highly effective for enhancing lipolysis and increasing energy expenditure within cells. Furthermore, Kuo's research has potential applications in lowering triglyceride and cholesterol levels, raising high-density lipoprotein levels, and addressing gut motility issues. Moreover, these compounds show promise in reducing neurogenic inflammation and acting as antidepressant agents. The synthesis of these compounds involves innovative methodologies, including coupling aminoalkylphenyl-sulfonamides with appropriately substituted epoxides.

Career Highlights: Chan-Hwa Kuo currently works at Merck & Company, Inc., a leading global healthcare company. His contributions to research and development have paved the way for new therapeutic options, particularly in the treatment of metabolic disorders.

Collaborations: Throughout his career, Kuo has collaborated with various esteemed colleagues, including Tesfaye Biftu and Conrad Santini. These partnerships have fostered a productive research environment, helping to propel advancements in health science and improve patient outcomes.

Conclusion: Chan-Hwa Kuo's inventive spirit and dedication to medicinal chemistry have led to groundbreaking advancements in treatments for diabetes and obesity. His work at Merck & Company, Inc., alongside talented colleagues, showcases the importance of innovation in overcoming some of the most pressing health challenges today. Kuo's inventions have the potential to make a significant impact on public health and continue to inspire future research in the field.

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