Celine Hayden

Title: Celine Hayden: Innovator in Plant-Based Vaccines

Introduction

Celine Hayden is a prominent inventor based in San Luis Obispo, California, known for her groundbreaking work in the field of plant-based vaccines. With a total of six patents to her name, she has made significant contributions to the development of innovative solutions for animal health.

Latest Patents

One of her latest patents focuses on the expression of Porcine Epidemic Diarrhea Virus (PEDV) sequences in plants. This invention provides a plant-produced vaccine for PEDV, where the Spike protein of the virus is expressed in a plant. The process involves introducing a construct into the plant that comprises a promoter preferentially directing expression to the seed, a nucleic acid encoding the Spike protein, and a nucleic acid targeting expression to the endoplasmic reticulum. The plant is capable of expressing the S1 polypeptide at levels of at least 10 mg/kg of seed. When administered orally to animals, this vaccine elicits a protective serum antibody response.

Another significant patent involves a plant-produced vaccine comprising an AG2 polypeptide from Coccidioides, which is responsible for Valley Fever disease. This invention outlines vaccines, methods of producing them, and methods of using them to generate a protective response when administered to animals. The AG2 polypeptide is expressed in a plant or plant part, linked to a promoter that directs expression to seed tissue. The polypeptide can be targeted to various cellular compartments, including the cell wall, vacuole, or endoplasmic reticulum, enhancing its expression levels.

Career Highlights

Celine has worked with notable companies such as Applied Biotechnology Institute, Inc. and Mazen Animal Health Inc. Her work has been instrumental in advancing the field of veterinary vaccines, particularly through her innovative approaches to utilizing plant systems for vaccine production.

Collaborations

Throughout her career, Celine has collaborated with esteemed colleagues, including John A. Howard and Erin Egelkrout. These partnerships have contributed to her success and the advancement of her research.

Conclusion

Celine Hayden's contributions to the field of plant-based vaccines demonstrate her commitment to innovation and animal health. Her patents reflect a deep understanding of biotechnology and its potential to address significant health challenges in the veterinary field.