The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 11, 2018

Filed:

Mar. 06, 2014
Applicant:

Applied Biotechnology Institute, Inc., San Luis Obispo, CA (US);

Inventors:

John Howard, Cayucos, CA (US);

Celine Hayden, San Luis Obispo, CA (US);

Rafael Jimenez-Flores, San Luis Obispo, CA (US);

Assignee:

Applied Biotechnology Institute, Inc., San Luis Obsipo, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/82 (2006.01); A61K 39/12 (2006.01); A61K 39/21 (2006.01); A61K 39/29 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/8257 (2013.01); A61K 39/12 (2013.01); A61K 39/21 (2013.01); A61K 39/292 (2013.01); C12N 15/8258 (2013.01); A61K 2039/517 (2013.01); A61K 2039/542 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55544 (2013.01); C12N 2740/16034 (2013.01);
Abstract

Increased antigenicity of a membrane-bound polypeptide produced from a plant is provided in a process in which extraction of the polypeptide or other compounds from the plant is such that phospholipids are associated with the polypeptide. Reducing fat by supercritical fluid extraction increases antigenicity of such plant-produced membrane-bound polypeptides. Methods and means of producing such membrane-bound polypeptides are provided. Methods to produce a protective response in animals are provided by administering to the animal the membrane-bound polypeptide. Binding of antibody specific to the membrane-bound polypeptide is increased. The process provides for increased preferred formation of the membrane-bound polypeptide. Stability of the membrane-bound polypeptide is increased when the plant material is defatted.


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