Catherine DeBrosse

Title: The Innovative Contributions of Catherine DeBrosse

Introduction

Catherine DeBrosse is a prominent inventor based in Norristown, PA (US). She has made significant strides in the field of medical imaging, particularly through her innovative patents. With a total of 2 patents, her work focuses on advanced imaging techniques that enhance the detection and measurement of critical biochemical markers in vivo.

Latest Patents

One of her latest patents is titled "Chemical exchange saturation transfer (CEST) imaging of lactate." This CEST imaging technique, combined with MR scanning, serves as an MRI method for detecting levels of lactate in vivo. The process involves obtaining a lactate CEST MRI map of a patient's body slice, followed by the administration of a contrast agent such as pyruvate, glucose, or glutamine. A post-administration CEST MRI map is then obtained, and the differences in the spatial maps indicate the level of lactate expression in the tissue of interest.

Another notable patent is "CEST MRI methods for imaging glutaminolysis in cancer." This method utilizes CEST imaging and MR scanning to measure glutaminase-mediated tumors. It capitalizes on the fact that glutamine does not exhibit a significant CEST effect, while glutamate does. Initially, a glutamate CEST MRI map of the tumor area is obtained, followed by the injection of L-glutamine or a glutaminase blocker. The resulting spatial maps reveal the level of glutaminase expression in the tumor.

Career Highlights

Catherine DeBrosse is affiliated with the University of Pennsylvania, where she continues to contribute to the advancement of medical imaging technologies. Her innovative work has positioned her as a key figure in her field, and her patents reflect her commitment to improving diagnostic methods.

Collaborations

Catherine has collaborated with notable colleagues such as Ravinder Reddy and Hari Hariharan. These partnerships have further enriched her research and development efforts, leading to groundbreaking advancements in medical imaging.

Conclusion

Catherine DeBrosse's contributions to the field of medical imaging through her innovative patents demonstrate her expertise and dedication. Her work not only enhances diagnostic capabilities but also paves the way for future advancements in healthcare technology.