Company Filing History:
Years Active: 1996-2001
Title: Innovation in Nucleic Acid Detection: The Patented Work of Carol Villnave Johnson
Introduction: Carol Villnave Johnson, based in Stowe, MA, has made significant contributions to the field of molecular biology through her patented inventions. With three patents to her name, Johnson has focused on improving methodologies for the detection and analysis of nucleic acids, dramatically enhancing the capabilities in this important area of research.
Latest Patents: Johnson's recent patents include groundbreaking techniques for in-situ hybridization. One of her notable inventions is centered on the "In-situ hybridization of single-copy and multiple-copy nucleic acid sequences." This innovative patent presents improved methodologies that yield major increases in resolution, sensitivity, and simplicity in comparison to previously known techniques. Her methods are capable of detecting even a single-copy of a specific nucleic acid, whether DNA or RNA, under controlled conditions. This technology can identify localized nucleic acids within chromosomes, nucleus, or cytoplasm and employs a variety of non-isotopic labels and detection means. Furthermore, the invention is also available in kit form for clinical and diagnostic laboratories, allowing relatively unskilled personnel to conduct accurate and reproducible detection of nucleic acids.
Another significant patent involves "Detection of individual gene transcription and splicing." This innovation reveals in situ hybridization methods that allow for the differential detection of RNA and the corresponding gene from which it is transcribed, all while preserving the spatial relationship. It also enables the simultaneous detection of two alleles of the same gene within a single cell and offers techniques for monitoring both normal and defective RNA splicing.
Career Highlights: Carol Villnave Johnson is currently affiliated with the University of Massachusetts, where she continues to advance scientific understanding and innovation in molecular biology. Her work exemplifies dedication to pushing the boundaries of knowledge through research that holds immense potential for clinical applications.
Collaborations: Throughout her career, Johnson has collaborated with esteemed colleagues, including Jeanne B. Lawrence and Yigong Xing. These partnerships highlight the interdisciplinary approach necessary for driving innovation and expanding the horizons of current scientific methodologies.
Conclusion: Carol Villnave Johnson's pioneering inventions in nucleic acid detection contribute significantly to both the scientific community and practical applications in clinical settings. Her work exemplifies the importance of innovation in the continuing advancement of molecular biology, reflecting a commitment not only to research but also to the broader implications of her findings in the world of healthcare and diagnostics.