Carol B Fowler

Title: **Innovative Contributions of Carol B. Fowler in Histological Methods**

Introduction

Carol B. Fowler, based in Rockville, MD, has made significant strides in biomedical innovations through her two patents. Her pioneering work primarily focuses on improving methods for tissue analysis, which is crucial for histological examinations.

Latest Patents

Fowler's latest patents are centered around Pressure-assisted Molecular Recovery (PAMR) of biomolecules, Pressure-assisted Antigen Retrieval (PAAR), and Pressure-assisted Tissue Histology (PATH). These patents describe an innovative method for reversing fixation-induced cross-linking in tissue specimens that have been preserved for histological examination. Specifically, the method involves exposing the fixed tissue to a liquid under elevated temperature and pressure conditions, sufficient to reverse the fixation-induced cross-linking, restoring antigenicity to proteins. This process subsequently enhances molecular and proteomic analysis of preserved tissue specimens. Additionally, the patents disclose techniques for processing tissues under elevated pressure conditions, which improve the perfusion of liquid reagents into the tissues and significantly reduce overall processing times.

Career Highlights

Throughout her career, Carol B. Fowler has worked in esteemed institutions, notably with the United States Government as represented by the Department of Veterans Affairs and the United States of America as represented by the Secretary of Defense on behalf of the Armed Forces Institute of Pathology. Her contributions in these organizations underscore her commitment to advancing histological methodologies.

Collaborations

Fowler has collaborated with noted professionals including Timothy J. O'Leary and Jeffrey T. Mason. Their collective expertise has enhanced the innovation and application of Fowler’s patented inventions in various clinical and research settings.

Conclusion

Carol B. Fowler's contributions to the field of histology through her patents on pressure-assisted techniques signify a notable advancement in tissue analysis. Her work not only facilitates better molecular understanding in preserved specimens but also stands as a testament to the importance of innovation in medical research. Her achievements inspire future generations of inventors and researchers aiming to improve scientific methodologies.