Carmen Arnalot Aguilar

Title: Carmen Arnalot Aguilar: Innovator in Pharmaceutical Chemistry

Introduction

Carmen Arnalot Aguilar is a notable inventor based in Gerona, Spain. She has made significant contributions to the field of pharmaceutical chemistry, particularly in the development of enantioselective processes for drug synthesis. Her work has implications for the production of beta-adrenergic blocking agents, which are essential in treating various cardiovascular conditions.

Latest Patents

Carmen holds a patent for an enantioselective process for the preparation of levobunolol. This invention presents a new and industrially advantageous method for synthesizing levobunolol without the need for resolving racemic bunolol. The process involves the enantioselective synthesis of an oxiranic intermediate, which is subsequently reacted with tert-butylamine. The method utilizes 5-hydroxy-3,4-dihydro-1(2H)-naphthalenone and (R)-(-)epichlorhydrine in an aprotic solvent, employing a strong base at temperatures exceeding 90°C. This results in the formation of the chiral oxirane intermediate with over 95% optical purity.

Career Highlights

Carmen is currently associated with Medicham, S.A., where she continues to advance her research in pharmaceutical innovations. Her expertise in enantioselective synthesis has positioned her as a key figure in her field.

Collaborations

Carmen has collaborated with notable colleagues, including Alberto Stampa Diez Del Corral and Pelayo Camps Garcia. These partnerships have fostered a collaborative environment that enhances the research and development of innovative pharmaceutical solutions.

Conclusion

Carmen Arnalot Aguilar's contributions to pharmaceutical chemistry, particularly through her patent for the synthesis of levobunolol, highlight her role as an innovator in the field. Her work not only advances scientific knowledge but also has practical applications in medicine.