Company Filing History:
Years Active: 2002-2006
Title: Innovations in Cardiac Gene Therapy by Carmelo A Milano
Introduction
Carmelo A Milano is a prominent inventor based in Durham, NC (US), known for his significant contributions to the field of gene therapy, particularly in enhancing myocardial function. With a total of 2 patents, his work focuses on innovative solutions for treating chronic heart failure and other cardiac diseases.
Latest Patents
One of his latest patents involves the use of exogenous β-adrenergic receptor and β-adrenergic receptor kinase gene constructs to enhance myocardial function. This invention addresses gene therapy for chronic heart failure and other cardiac conditions characterized by a reduced number or functionality of myocardial beta-adrenergic receptors (β-AR). The patent describes how β-AR receptor function can be augmented in transgenic animals through the delivery and expression of a beta-2-adrenergic receptor gene or a gene encoding a beta adrenergic receptor kinase inhibitor. This results in improved in vivo left ventricular function. The invention includes recombinant plasmid vectors, alternative beta-adrenergic receptor gene delivery strategies, and transgenic mice carrying various β-AR transgenes.
Career Highlights
Carmelo A Milano is affiliated with Duke University, where he continues to advance research in cardiac gene therapy. His innovative approaches have garnered attention in the scientific community, contributing to the understanding and treatment of heart diseases.
Collaborations
He has collaborated with notable figures in the field, including Walter J Koch and Robert J Lefkowitz, enhancing the impact of his research through shared expertise and knowledge.
Conclusion
Carmelo A Milano's work in gene therapy represents a significant advancement in the treatment of cardiac diseases. His innovative patents and collaborations highlight his commitment to improving myocardial function and patient outcomes.