Carmela Abraham

Title: Carmela Abraham: Innovator in Gene Expression Modulation

Introduction

Carmela Abraham is a notable inventor based in Boston, MA, who has made significant contributions to the field of gene expression modulation. With a total of two patents to her name, her work focuses on innovative methods to enhance gene expression, particularly related to the Klotho gene.

Latest Patents

Abraham's latest patents include groundbreaking methods for increasing gene expression. One patent discusses compositions and methods for modulating gene expression, specifically targeting the Klotho gene. This patent outlines a method that involves administering a binding molecule to a cell, which binds to an RNA transcript transcribed from a chromosomal region near the Klotho gene. This RNA transcript does not encode a Klotho protein, yet plays a crucial role in gene expression modulation. Another patent elaborates on methods for increasing Klotho gene expression in human cells by introducing a CRISPR enzyme and a guide RNA that is complementary to a target sequence within or near the Klotho gene. This innovative approach associates the guide RNA or CRISPR enzyme with a transcriptional activation domain, showcasing Abraham's commitment to advancing genetic research.

Career Highlights

Throughout her career, Carmela Abraham has worked with several prominent companies, including Advantage Therapeutics, Inc. and Klogenix LLC. Her experience in these organizations has allowed her to collaborate with leading experts in the field and contribute to significant advancements in gene therapy and expression modulation.

Collaborations

Abraham has collaborated with notable colleagues such as Ci-Di Chen and Ella Zeldich. These partnerships have further enriched her research and development efforts, leading to innovative solutions in gene expression.

Conclusion

Carmela Abraham's work in gene expression modulation represents a significant advancement in biotechnology. Her innovative patents and collaborations highlight her dedication to enhancing our understanding of genetic mechanisms. Through her contributions, she continues to pave the way for future discoveries in the field.