The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2023
Filed:
Dec. 04, 2018
Applicant:
Klogenix Llc, Boston, MA (US);
Inventors:
Assignee:
KLOGENIX LLC, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C12N 9/22 (2006.01); C12N 15/67 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C12N 5/0686 (2013.01); C12N 9/22 (2013.01); C12N 15/67 (2013.01); C12N 2310/20 (2017.05); C12N 2501/115 (2013.01);
Abstract
The present disclosure relates to compositions and methods for modulating gene expression and in particular to compositions and methods for increasing expression of Klotho. For example, the present disclosure provides methods for increasing expression of a Klotho gene in a human cell comprising introducing into the cell a CRISPR enzyme and a guide RNA comprising a guide sequence that is substantially complementary to a target sequence within or near the Klotho gene, wherein the guide RNA or the CRISPR enzyme associates with a transcriptional activation domain.