Carlo Mannucci

Title: Carlo Mannucci: Innovator in Pharmaceutical Chemistry

Introduction

Carlo Mannucci is a notable inventor based in Pomezia, Italy. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the preparation of zofenopril calcium salt. With a total of 2 patents to his name, Mannucci's work has had a meaningful impact on the industry.

Latest Patents

Mannucci's latest patents focus on the process for the preparation of zofenopril calcium salt. The first patent describes a method that involves the reaction of S(−)-3-benzoylthio-2-methylpropanoic acid chloride with cis-4-phenylthio-L-proline in water at a pH ranging from 9.0 to 9.5. This process allows for the recovery of zofenopril in its acidic form. The subsequent steps include salification of the acid zofenopril with a potassium salt in an alcoholic solution, followed by the conversion of the potassium salt to the calcium salt. This conversion is achieved by adding a zofenopril potassium salt aqueous solution to a CaCl aqueous solution at a temperature of 70-90°C, with simultaneous seeding to promote the precipitation of polymorph A.

Career Highlights

Throughout his career, Carlo Mannucci has worked with prominent companies in the pharmaceutical sector, including Menarini Ricerche S.p.A. His expertise in the field has allowed him to develop innovative processes that enhance the purity and efficacy of pharmaceutical compounds.

Collaborations

Mannucci has collaborated with esteemed colleagues such as Raffaello Giorgi and Antonio Giachetti. These partnerships have contributed to the advancement of his research and the successful development of his patents.

Conclusion

Carlo Mannucci's contributions to pharmaceutical chemistry, particularly through his innovative processes for zofenopril calcium salt, highlight his role as a significant inventor in the field. His work continues to influence the industry and pave the way for future advancements.