Carina A McAdams

Title: Carina A McAdams: Innovator in Pharmaceutical Chemistry

Introduction

Carina A McAdams is a notable inventor based in Corpus Christi, TX (US). She has made significant contributions to the field of pharmaceutical chemistry, particularly in the development of processes for producing enantiomeric salts of ibuprofen. With a total of 2 patents to her name, her work has implications for the pharmaceutical industry.

Latest Patents

One of her latest patents involves the selective precipitation of α-aryl carboxylic acid salts. This process allows for the production of S(+)-ibuprofen or R(-)-ibuprofen L-lysinate salt from a mixture containing enantiomers of ibuprofen and L-lysine. The method ensures that the quantity of L-lysine does not exceed a molar equivalent of one of the enantiomers in the ibuprofen mixture. The process includes holding the precipitate and reaction mixture at a second temperature to facilitate the redissolution of the first precipitate, allowing the other ibuprofen enantiomer to precipitate out in salt form. Additionally, optically active ibuprofen can be racemized by heating it at temperatures ranging from 100°C to 300°C in the absence of other materials.

Career Highlights

Carina A McAdams has established herself as a key figure in her field through her innovative approaches to pharmaceutical processes. Her work at Hoechst Celanese Corporation has been instrumental in advancing the understanding and application of enantiomeric compounds in medicine.

Collaborations

Throughout her career, Carina has collaborated with esteemed colleagues such as Apurba Bhattacharya and John R Fritch. These partnerships have contributed to her success and the advancement of her research.

Conclusion

Carina A McAdams is a pioneering inventor whose work in pharmaceutical chemistry continues to influence the industry. Her innovative processes for producing enantiomeric salts demonstrate her commitment to advancing medical science.