Company Filing History:
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1 out of 389 
Years Active: 1988-1989
Title: The Innovative Contributions of Calvin P. Vary
Introduction
Calvin P. Vary is a notable inventor based in Califon, NJ (US). He has made significant contributions to the field of biotechnology, particularly in the development of methods for polynucleotide assays. With a total of 4 patents to his name, Vary's work has advanced the understanding and application of genetic testing.
Latest Patents
One of Vary's latest patents is a method and kit for polynucleotide assay that includes a primer-dependent DNA approach. This innovative technique involves a probe polynucleotide that binds to a target nucleotide sequence in the nucleic acid of a biological sample. The probe is enzymatically extended in the 3'-direction using a mixture of nucleoside triphosphates, which includes at least one detectably labeled triphosphate. After separating the extended hybrid from unreacted nucleoside triphosphates, the incorporated detectably-modified nucleotides are determined. In certain forms, the 3'-terminal nucleotide of the probe is selected to form a matched pair with some sample strands, while forming a mismatched pair with others. This specificity allows for precise detection, especially when using a primer-dependent enzyme that lacks 3'-exonuclease activity.
Another significant patent is the homogeneous polynucleotide displacement assay method kit and reagent. In this method, an RNA signal strand is displaced from a probe strand by a target nucleotide sequence. Without the need for separation, a digestion enzyme selective for the displaced RNA digests it to nucleoside phosphates, including ADP. The digestion products can be detected by phosphorylating the ADP to ATP and measuring the ATP through bioluminescence.
Career Highlights
Throughout his career, Calvin P. Vary has worked with prominent companies such as Allied Corporation and Genetics Institute, Inc. His experience in these organizations has contributed to his expertise in the field of biotechnology and patent development.
Collaborations
Vary has collaborated with notable individuals in his field, including Steven E. Diamond and Neil M. Wolfman. These collaborations have likely enriched his work and expanded the impact of his inventions.
Conclusion
Calvin P. Vary's innovative contributions to biotechnology, particularly in polynucleotide assays, have established him as a significant figure in the field.