Calum Macaulay

Title: Innovations of Calum Macaulay in Optical Imaging

Introduction

Calum Macaulay is a prominent inventor based in Vancouver, Canada, known for his significant contributions to the field of optical imaging. With a total of seven patents to his name, Macaulay has developed advanced systems that enhance the understanding and assessment of biological tissues.

Latest Patents

One of his latest patents is focused on systems for optical imaging of biological tissues. This innovation involves a fiber-based polarization sensitive optical coherence tomography (PS-OCT) system that utilizes a new polarization diversity detection (PDD) scheme, eliminating the need for active polarization modulating components. The system allows for the determination of sample retardation from the amplitudes of arbitrarily-oriented x- and y-components of the reflected light. Additionally, a hybrid custom 50/50 coupler with single-mode fiber inputs and polarization maintaining (PM) fiber outputs is employed to combine light from the sample and reference arms of an interferometer. Another embodiment of this patent provides a system designed for co-registered autofluorescence-optical coherence tomography (AF-OCT) imaging, where AF excitation light is introduced, and collected AF light is extracted at a fiber optic rotary joint (FORJ) equipped with an embedded dichroic mirror. Furthermore, Macaulay has developed apparatus and methods for the automated assessment of tissue pathology. These methods involve computing an index based on measures of various morphological features of cell nuclei in the tissue, which can be performed either automatically or semi-automatically. The index value can predict outcomes and is determined by computing discriminant scores for the cell nuclei and classifying them into bins based on these scores.

Career Highlights

Throughout his career, Calum Macaulay has worked with notable organizations such as Xillix Technologies Corporation and the British Columbia Cancer Agency Branch. His work has significantly impacted the field of medical imaging and tissue analysis.

Collaborations

Macaulay has collaborated with esteemed colleagues, including Branko Mihael Palcic and Stephen C-t Lam, contributing to advancements in optical imaging technologies.

Conclusion

Calum Macaulay's innovative work in optical imaging has led to significant advancements in the assessment of biological tissues, showcasing his expertise and dedication to the field. His contributions continue to influence medical imaging technologies and improve diagnostic capabilities.