Homewood, AL, United States of America

C Ryan Miller


Average Co-Inventor Count = 4.0

ph-index = 2

Forward Citations = 11(Granted Patents)


Company Filing History:


Years Active: 2003-2004

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2 patents (USPTO):Explore Patents

Title: Innovations in Cancer Treatment by C Ryan Miller

Introduction

C Ryan Miller is an accomplished inventor based in Homewood, AL (US). He has made significant contributions to the field of cancer treatment through his innovative approaches. With a total of 2 patents, Miller's work focuses on enhancing the efficacy of cancer therapies.

Latest Patents

Miller's latest patents include a groundbreaking invention titled "Molecular chemotherapy enhancement of radiotherapy." This invention presents a novel approach for cancer treatment by combining gene therapy with radiation therapy to increase cytotoxicity in malignant cells. The research demonstrates that utilizing the cytosine deaminase gene along with 5-fluorocytosine serves as an effective radiosensitizing strategy. This method may lead to improved tumor control while minimizing normal tissue toxicity compared to traditional systemic administration of 5-fluorouracil. The invention also describes a noninvasive method for continuous in vivo monitoring of 5-fluorouracil production using magnetic resonance spectroscopy. Additionally, Miller has constructed an adenovirus that encodes the cytosine deaminase gene, which selectively replicates in tumor cells with a defective p53 pathway. Another adenovirus has been developed that encodes a fusion protein of cytosine deaminase and uracil phosphoribosyltransferase.

Career Highlights

C Ryan Miller is associated with the UAB Research Foundation, where he continues to advance his research in cancer therapies. His work has the potential to significantly impact the treatment landscape for cancer patients.

Collaborations

Miller has collaborated with notable colleagues, including Donald J Buchsbaum and G Yancey Gillespie, to further enhance the research and development of innovative cancer treatments.

Conclusion

C Ryan Miller's contributions to cancer treatment through his innovative patents highlight the importance of research and collaboration in the medical field. His work exemplifies the potential for advancements in therapy that can lead to better patient outcomes.

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