C Preston Linn

Title: C Preston Linn: Innovator in Nucleic Acid Detection

Introduction

C Preston Linn is a distinguished inventor based in Durham, NC (US), known for his significant contributions to the field of nucleic acid detection. With a total of 12 patents to his name, Linn has developed innovative methods that enhance the accuracy and efficiency of detecting nucleic acid target sequences.

Latest Patents

Among his latest patents, Linn has introduced groundbreaking technologies such as "Universal probes and methods for detection of nucleic acids." This invention utilizes signal primers that employ fluorescence quenching mechanisms to detect nucleic acid target sequences. The signal primer consists of a first and a second oligonucleotide, which are partially single-stranded and partially double-stranded. In the presence of a target, the second oligonucleotide is displaced from the first, leading to a conformational change in a reporter probe. This change alters the distance between a donor/quencher dye pair linked to the reporter probe, resulting in a detectable change in fluorescence that indicates the presence of the target sequence.

Another notable patent is "Detection of nucleic acids by strand displacement." This method employs detector nucleic acids that consist of at least two oligonucleotides, also partially single-stranded and partially double-stranded. The configuration allows for the detection of nucleic acid target sequences through fluorescence quenching mechanisms. In the presence of a target, the second oligonucleotide(s) is/are displaced from the first, increasing the distance between the donor and acceptor dyes, which can be detected as an indication of the target sequence's presence.

Career Highlights

Throughout his career, C Preston Linn has worked with prominent companies such as Becton Dickinson and Company Limited and Beckon, Dickson and Company. His work in these organizations has allowed him to refine his expertise in nucleic acid detection technologies and contribute to advancements in the field.

Collaborations

Linn has collaborated with notable professionals in his field, including J Bruce Pitner and James G Nadeau. These collaborations have further enriched his research and development efforts, leading to innovative solutions in nucleic acid detection.

Conclusion

C Preston Linn's contributions to the field of nucleic acid detection through his patents and collaborations highlight his role as a leading inventor. His innovative methods continue to advance the capabilities of detecting nucleic acids,