Bryan Charleston

Title: Bryan Charleston - Innovator in Virus Capsid Production

Introduction

Bryan Charleston is a notable inventor based in Pirbright, GB. He has made significant contributions to the field of virology, particularly in the production of empty virus capsids. His innovative work has implications for vaccine development and other biotechnological applications.

Latest Patents

Charleston holds a patent for a construct designed to produce empty virus capsids. This invention provides a construct that, when expressed in a host cell, is capable of generating empty virus capsids. The construct includes a nucleotide sequence encoding a capsid precursor protein, a nucleotide sequence encoding a protease that cleaves the capsid precursor protein, and a control element that regulates the expression of the protease. This ensures that the protease is expressed at a level sufficient to cleave the capsid precursor protein without causing significant toxicity to the host cell. The invention also encompasses a vector and a host cell containing such a construct, facilitating the generation of empty virus capsids.

Career Highlights

Charleston is affiliated with The Pirbright Institute, where he conducts his research and development activities. His work at the institute has positioned him as a key figure in the field of virology, contributing to advancements in vaccine technology and viral research.

Collaborations

Charleston has collaborated with notable colleagues, including Ian Jones, enhancing the impact of his research through shared expertise and knowledge.

Conclusion

Bryan Charleston's innovative work in the production of empty virus capsids represents a significant advancement in virology. His contributions are vital for future developments in vaccine technology and biotechnological applications.