Company Filing History:
2 out of 6 
1 out of 2,202 
Years Active: 1995-1998
Title: **The Innovative Contributions of Bruce W. Penman**
Introduction
Bruce W. Penman is an accomplished inventor based in Salem, Massachusetts, known for his significant contributions to the field of biochemistry and genetic engineering. With a total of two patents under his name, Penman has played a pivotal role in advancing methodologies for detecting receptor-ligand complexes and improving promoter sequence activity measurement in mammalian cells.
Latest Patents
Penman's latest patents demonstrate his innovative approach to biotechnological challenges. One of his notable inventions is a method for detecting a receptor-ligand complex using a cytochrome P450. This improved technique notably enhances the measurement of the activity of a promoter sequence in mammalian cells by utilizing a reporter cassette that encodes a cytochrome P450 with a polyadenylation signal sequence as the reporter gene. Furthermore, he has developed a human cell line, MCL-5, which stably expresses multiple cytochrome P450 enzymes. This cell line is particularly useful for mutagenicity, toxicity, and metabolism studies, demonstrating Penman's focus on impactful research.
Career Highlights
Throughout his career, Penman has worked with notable organizations, including Gentest Corporation and the United States of America as represented by the Secretary of Health and Human Services. His innovative research and methodologies have laid important groundwork in the field of genetic research and cellular biology.
Collaborations
Collaboration has been a key element of Penman's success. He has worked alongside esteemed colleagues such as Charles L. Chrespi and Frank J. Gonzalez. Their combined expertise has undoubtedly enhanced the quality of research and innovation produced within their respective fields.
Conclusion
In summary, Bruce W. Penman's contributions to the field of biotechnology and genetics through his inventions and collaborations highlight his status as a leading innovator. His patents not only showcase his creativity but also serve as essential tools for scientific research and advancement.