Company Filing History:
2 out of 3,685 
1 out of 41 Years Active: 2010-2013
Title: Bruce T Lotz: Innovator in Pharmaceutical Chemistry
Introduction
Bruce T Lotz is a notable inventor based in Yardville, NJ (US). He has made significant contributions to the field of pharmaceutical chemistry, particularly in the development of HIV protease inhibitors. With a total of 3 patents, Lotz has demonstrated his expertise and commitment to innovation in the pharmaceutical industry.
Latest Patents
One of Lotz's latest patents is focused on the process for preparing atazanavir bisulfate, a crucial HIV protease inhibitor. This innovative process involves reacting a solution of atazanavir free base with concentrated sulfuric acid, ensuring that less than about 15% by weight of the free base is reacted. The method includes adding seeds of Form A crystals of atazanavir bisulfate to the reaction mixture. As the bisulfate crystals form, additional concentrated sulfuric acid is introduced in multiple stages, following a cubic equation to facilitate the formation of Form A crystals. Furthermore, Lotz has developed a novel form of atazanavir bisulfate, designated as Form E3, which is a highly crystalline triethanolate solvate of the bisulfate salt derived from ethanol.
Career Highlights
Throughout his career, Bruce T Lotz has worked with prominent companies in the pharmaceutical sector, including Bristol-Myers Squibb Company. His work has significantly impacted the development of effective treatments for HIV, showcasing his dedication to improving public health through innovative solutions.
Collaborations
Lotz has collaborated with esteemed colleagues such as Soojin Kim and Mary F Malley. These partnerships have further enhanced his research and development efforts in the pharmaceutical field.
Conclusion
In summary, Bruce T Lotz is a distinguished inventor whose work in pharmaceutical chemistry has led to important advancements in HIV treatment. His innovative processes and collaborations reflect his commitment to improving healthcare outcomes through scientific research and development.