Location History:
- Merion Station, PA (US) (1998 - 2003)
- Marion Station, PA (US) (2008)
- Avon, CT (US) (2013 - 2020)
Company Filing History:
7 out of 762 
4 out of 3,540 
3 out of 2,611 
Years Active: 1998-2020
Title: Innovations by Bruce T Liang: Advancements in Stroke and Cardiac Disease Treatment
Introduction
Bruce T Liang, an accomplished inventor based in Merion Station, PA, has made significant contributions to medical science with a total of 13 patents to his name. His innovative work primarily focuses on developing methods and compositions for treating critical health conditions such as stroke and cardiac diseases.
Latest Patents
Among his most recent innovations are methods for pharmacologic treatment of stroke, where he describes approaches to treat individuals who have suffered a stroke by administering a pharmaceutical composition that includes an antagonist of the P2X4 receptor. This innovative treatment can be applied in the acute phase of stroke, with the potential to be used alongside thrombolytic therapies or clot-removal procedures.
Another notable patent involves compositions and methods aimed at treating cardiac diseases. He has explored phosphonate and phosphinate N-methanocarba derivatives of AMP, particularly focusing on MRS2339, a derivative with promising capabilities. MRS2339 operates on P2X receptors, which are vital in the functioning of ligand-gated ion channels. The synthesized analogues, which were tested in calsequestrin-overexpressing mice—a genetic model of heart failure—showed significant improvements in heart contractile function when administered via mini-osmotic pumps, showcasing the expanded possibilities for treating heart failure.
Career Highlights
Throughout his career, Bruce has been affiliated with the University of Connecticut, contributing to both research and practical applications of his inventions. His experience in a prestigious academic institution has undoubtedly influenced his innovative thinking and patent development.
Collaborations
Bruce T Liang has collaborated with experts in his field, including Kenneth Alan Jacobson and Bhalchandra V Joshi. These partnerships have led to fruitful research endeavors and advancements in therapeutic methods that aim to enhance patient care.
Conclusion
In conclusion, Bruce T Liang stands out as a prominent inventor in the realm of medical innovation. His dedication to improving treatments for critical health conditions through scientific exploration is evident in his patent portfolio. With each invention, he has taken significant strides towards enhancing healthcare outcomes, particularly for stroke and cardiac disease patients.