Company Filing History:
Years Active: 2002-2010
Title: Innovations and Contributions of Bruce Sherf
Introduction
Bruce Sherf is a notable inventor based in Spencer, Ohio, who has made significant contributions to the field of gene expression and biotechnology. With a total of 12 patents to his name, Sherf's work focuses on innovative methods for activating endogenous genes, which have implications for understanding human diseases and development.
Latest Patents
One of Sherf's latest patents is titled "Compositions and methods for non-targeted activation of endogenous genes." This invention is directed towards activating gene expression or causing over-expression of a gene through recombination methods in situ. The invention outlines methods for expressing an endogenous gene in a cell at levels higher than those typically found. In one embodiment, the expression of an endogenous gene is activated following integration into the cell by non-homologous or illegitimate recombination of a regulatory sequence. Additionally, the invention provides methods for identifying, activating, isolating, and expressing genes that are currently undiscoverable, as no target sequence is necessary for integration. This advancement allows for the activation and isolation of endogenous genes associated with human disease and development without prior knowledge of their sequence or function.
Career Highlights
Throughout his career, Bruce Sherf has worked with prominent companies in the biotechnology sector, including Athersys, Inc. and Abt Holding Company. His experience in these organizations has contributed to his expertise in gene expression technologies and innovative research methodologies