Company Filing History:
4 out of 2,489 
1 out of 164,244 
Years Active: 1999-2011
Title: Bruce J Berne: Innovator in Binding Affinity Calculations
Introduction
Bruce J Berne is a notable inventor based in Irvington, NY (US). He holds a total of 5 patents that contribute significantly to the field of thermodynamics and binding affinity calculations. His work has implications in biochemistry and molecular biology, particularly in understanding protein-ligand interactions.
Latest Patents
One of his latest patents involves methods of calculating differences of binding affinities between congeneric pairs of ligands by way of a displaced solvent functional. This technique exhaustively enumerates the thermodynamic properties of water molecules that solvate the active site of a protein in its apostate. The process includes sampling configurations of the solvating water, extracting thermodynamic information, and computing relative binding affinities of congeneric compounds that bind to the protein. The methodology constructs a three-dimensional hydration thermodynamics map of the protein active site, allowing for a deeper understanding of how tighter binding ligands can influence hydration sites.
Career Highlights
Throughout his career, Bruce J Berne has worked with prestigious institutions such as Columbia University and IBM. His contributions to the field have been recognized through his innovative patents and research.
Collaborations
Some of his notable coworkers include Thomas R Young and Robert Abel, who have collaborated with him on various projects.
Conclusion
Bruce J Berne's work in binding affinity calculations and thermodynamics has made a significant impact in the scientific community. His innovative approaches continue to advance our understanding of protein interactions and ligand binding.