Bruce H Littman

Title: Bruce H Littman: Innovator in Biologically Active Peptides

Introduction

Bruce H Littman is a notable inventor based in Stonington, CT (US). He has made significant contributions to the field of biotechnology, particularly in the development of human-derived cell-permeable peptides. With a total of 4 patents, his work focuses on innovative methods for delivering biologically active molecules into cells.

Latest Patents

Littman's latest patents include groundbreaking compositions for conjugates, including fusion proteins, designed to treat various medical conditions. These embodiments utilize a 60-amino acid human homeodomain, derived from human HOX genes, to facilitate the translocation of functional and regulatory peptides across cell and nuclear membranes. This innovative approach allows for the delivery of biologically active molecules, such as nucleic acids, without triggering unwanted immune responses. Furthermore, his inventions have the potential to cross the blood-brain barrier, enabling access to the central nervous system (CNS) for therapeutic purposes.

Career Highlights

Throughout his career, Bruce H Littman has worked with prominent companies in the pharmaceutical industry, including Pfizer Corporation and Portage Pharmaceuticals Ltd. His experience in these organizations has contributed to his expertise in the development of advanced therapeutic solutions.

Collaborations

Littman has collaborated with notable colleagues, including John F Thompson and Frank W Marcoux, further enhancing the impact of his work in the field of biotechnology.

Conclusion

Bruce H Littman stands out as an innovative inventor whose work in biologically active peptides has the potential to revolutionize therapeutic delivery methods. His contributions continue to influence advancements in medical treatments and biotechnology.