Location History:
- Irvine, CA (US) (2004 - 2007)
- San Diego, CA (US) (1999 - 2011)
Company Filing History:
7 out of 577 
1 out of 349 
2 out of 832,966 Years Active: 1999-2011
Title: Bruce Blumberg: Innovator in Nuclear Receptor Research
Introduction
Bruce Blumberg is a prominent inventor based in San Diego, CA (US). He has made significant contributions to the field of nuclear receptor research, holding a total of 10 patents. His work has advanced our understanding of how certain receptors function in the body, particularly in relation to metabolism and drug interactions.
Latest Patents
One of Blumberg's latest patents is focused on steroid-activated nuclear receptors and their uses. This invention introduces a novel nuclear receptor known as the steroid and xenobiotic receptor (SXR). SXR is a broad-specificity sensing receptor that forms a heterodimer with RXR, allowing it to bind to and induce transcription from response elements in steroid-inducible cytochrome P450 genes. This receptor can respond to a wide range of natural and synthetic compounds, including therapeutic steroids and dietary steroids. The invention proposes that instead of having numerous receptors for each inducing compound, SXR can monitor aggregate levels of inducers to trigger the production of metabolizing enzymes in a coordinated metabolic pathway. Additionally, agonists and antagonists of SXR can be administered to achieve various therapeutic goals by modulating the metabolism of endogenous steroids or xenobiotics. Another significant patent involves human peroxisome proliferator-activated receptor gamma, which includes compositions and methods for obtaining these receptors, as well as the DNA sequences encoding them.
Career Highlights
Blumberg has worked at the Salk Institute for Biological Studies, where he has contributed to groundbreaking research in his field. His innovative work has led to advancements in understanding how nuclear receptors can be utilized in therapeutic applications.
Collaborations
Throughout his career, Blumberg has collaborated with notable scientists, including Ronald Mark Evans and Marianne E Greene. These collaborations have further enriched his research and contributed to the scientific community's understanding of nuclear receptors.
Conclusion
Bruce Blumberg's contributions to nuclear receptor research have had a profound impact on the field. His innovative patents and collaborations highlight his role as a leading inventor in this area. His work continues to influence therapeutic approaches and our understanding of metabolic processes.