Bruce A Cunningham

Title: Bruce A Cunningham: Innovator in Chromosomal Integration Technologies

Introduction

Bruce A Cunningham is a notable inventor based in San Diego, California. He has made significant contributions to the field of genetic engineering, particularly in the area of chromosomal integration technologies. With a total of three patents to his name, Cunningham's work has the potential to advance the capabilities of recombinant DNA technology.

Latest Patents

Cunningham's latest patents focus on "Chromosomal landing pads and related uses." These patents provide methods for the stable integration and expression of recombinant polynucleotides in host cells. The recombinant polynucleotides are typically integrated into the host genome at native chromosomal integration sites. The integration can be mediated by homologous recombination or by using a hybrid recombinase targeting specific chromosomal locations. The native chromosomal integration sites in the host cells support stable integration and strong transcription activities of foreign genes. These sites are present within or adjacent to specific genes in the CHO genome, including the ankyrin 2 gene (Ank2), cleavage and polyadenylation specific factor 4 gene (Cpsf4), C-Mos gene, and Nephrocystin-1/Mal gene. Additionally, the patents describe methods and nucleic acid molecules for inserting site-specific recombination sequences, known as chromosomal landing pads, into these specific chromosomal locations, as well as engineered host cells containing these landing pads.

Career Highlights

Cunningham is affiliated with The Scripps Research Institute, where he continues to innovate and contribute to the field of genetic research. His work has garnered attention for its potential applications in biotechnology and medicine.

Collaborations

Some of his notable coworkers include Vincent P Mauro and Wei Zhou, who have collaborated with him on various projects related to genetic engineering and recombinant technologies.

Conclusion

Bruce A Cunningham's contributions to chromosomal integration technologies highlight his role as a leading inventor in the field. His innovative patents pave the way for advancements in genetic engineering, showcasing the importance of his work in the scientific community.