This inventor holds 3 USPTO granted patents. Top assignee: London Biotechnology Limited. Active years: 1988-1995.
Company Filing History:
Years Active: 1988-1995
Title: Brian R Rabin: Innovator in Enzymatic Detection
Introduction
Brian R Rabin is a notable inventor based in Potters Bar, GB. He has made significant contributions to the field of enzymatic detection, holding a total of 3 patents. His work focuses on innovative methods for detecting analytes using hydrolase enzymes and novel substrates.
Latest Patents
Rabin's latest patents include an amplification assay for hydrolase enzymes. This method allows for the sensitive determination of hydrolase enzymes using novel substituted FAD substrates. The process involves hydrolyzing the substituted FAD substrates to FAD by the enzyme being detected. The FAD is then combined with an apoenzyme to form a holoenzyme, which initiates a reaction leading to a detectable product. When the hydrolase to be detected is phosphatase, the novel substrate is a phosphorylated derivative of FAD. A suitable apoenzyme for this method is apo-glucose oxidase, which provides exceptional sensitivity. Additionally, apo-D-amino acid oxidase can be utilized in a 'single pot' assay system.
Another significant patent by Rabin is an enzymic method of detecting analytes and novel substrates therefor. This method employs a small enzymically inactive peptide fragment of an enzyme, such as ribonuclease S-peptide, which is conjugated with a complementary fragment (S-protein) to form an enzyme. This enzyme catalyzes a primary reaction whose product leads to an essential coenzyme or prosthetic group for a second enzyme, which catalyzes a secondary reaction resulting in a detectable outcome indicating the presence of the analyte. The patent also discloses novel synthetic substrates for the primary reaction.
Career Highlights
Brian R Rabin is currently associated with London Biotechnology Limited, where he continues to advance his research and innovations in enzymatic detection. His work has garnered attention for its potential applications in various fields, including diagnostics and biochemistry.
Collaborations
Rabin has collaborated with notable colleagues, including Michael R Hollaway and Christopher J Taylorson. These collaborations have contributed to the development of his innovative patents and research.
Conclusion
Brian R Rabin is a distinguished inventor whose work in enzymatic detection has led to significant advancements in the field. His innovative patents reflect his commitment to enhancing detection methods, making a lasting impact