Company Filing History:
Years Active: 2010-2011
Title: Innovations in Antidepressant Therapeutics by Brian R. Kusche
Introduction
Brian R. Kusche is an accomplished inventor based in Missoula, MT (US). He has made significant contributions to the field of antidepressant therapeutics and imaging agents. With a total of 2 patents, his work focuses on enhancing the understanding and treatment of serotonin-related disorders.
Latest Patents
Kusche's latest patents include groundbreaking research on enantiomers of 2'-fluoralkyl-6-nitroquipazine. These compounds serve as serotonin transporter positron emission tomography (PET) imaging agents and antidepressant therapeutics. The patents detail racemic mixtures and individual enantiomers of fluorine-18 or carbon-11 radiolabeled 2'-alkyl-6-nitroquipazine ligands. These ligands act as serotonin transporter (SERT) tracers for PET imaging. The non-radioactive ligand forms exhibit therapeutic antidepressant properties, demonstrating in vitro and in vivo pharmacological binding profiles in rodent brains and human serotonin transporter (hSERT) expressing cells. Twelve 2'-alkyl-6-nitroquipazine ligands have shown potent binding in sub-nanomolar concentrations to the pre-synaptic SERT binding site, where established antidepressant drugs inhibit the re-uptake of serotonin (5-HT). In vivo tracer studies in rats and monkey PET scan trials have confirmed that the fluorine-18 and carbon-11 positron radionuclide labeled tracers function as quantitative tracers of specific binding to the SERT protein in live brains.
Career Highlights
Brian R. Kusche is affiliated with the University of Montana, where he continues to advance research in the field of pharmacology and imaging. His innovative work has the potential to significantly impact the treatment of depression and related disorders.
Collaborations
Kusche has collaborated with notable colleagues, including John M. Gerdes and David B. Bolstad. Their combined expertise contributes to the advancement of research in antidepressant therapeutics.
Conclusion
Brian R. Kusche's contributions to the field of antidepressant therapeutics and imaging agents highlight the importance of innovation in addressing mental health challenges. His work continues to pave the way for future advancements in this critical area of research.