Brian R Crane

Title: Inventor Brian R. Crane: Advancements in Heme-Binding Proteins and Nitric Oxide Synthases

Introduction

Brian R. Crane is a notable inventor based in Ithaca, NY, recognized for his contributions to biotechnology through innovative inventions. With a total of three patents, Crane’s work primarily focuses on methods for producing recombinant heme-binding proteins and nitric oxide synthases, which hold substantial applications in various research fields.

Latest Patents

Crane's most recent patents include:

1. **Methods of Producing Recombinant Heme-Binding Proteins and Uses Thereof** - This invention details methods for producing recombinant functional heme-binding proteins with complete heme incorporation, as well as the identification of agents that can modulate the activity of these proteins.

2. **Bacterial Nitric Oxide Synthases and Uses Thereof** - This patent relates to isolated nucleic acid molecules encoding nitric oxide synthases. The encoded proteins can be utilized for attaching nitrogen groups to target compounds and for synthesizing nitrogen-modified compounds using transgenic host cells. The invention also covers expression systems and host cells containing these nucleic acids, along with methods for recombinantly producing nitric oxide synthases.

Career Highlights

Brian R. Crane has held significant positions at reputable institutions. He worked at the California Institute of Technology and Cornell University, where he contributed to various research projects and advancements in his field. His expertise and contributions have established him as a key figure in the realm of biotechnology.

Collaborations

Throughout his career, Crane has collaborated with esteemed colleagues, including Harry B. Gray and Jay R. Winkler. These collaborations have led to impactful research and innovations that further enhance the understanding and application of his inventions.

Conclusion

In summary, Brian R. Crane's innovative patents and extensive collaboration within the scientific community underscore his significant contributions to biotechnology. His work on recombinant heme-binding proteins and nitric oxide synthases positions him as a crucial inventor in the ongoing development of biotechnological applications, paving the way for future advancements in the field.