Brian J Hardinge

Title: Brian J Hardinge: Innovator in Ceramide Preparation

Introduction

Brian J Hardinge is a notable inventor based in Brabourne Lees, GB. He has made significant contributions to the field of chemistry, particularly in the preparation of ceramides. His innovative approach has led to the development of a unique process that enhances the efficiency of ceramide production.

Latest Patents

Brian J Hardinge holds a patent for a process for the preparation of ceramides. This invention involves a two-step process that converts a 2-hydroximino-3-oxo-alkanoate into a 2-alkanoylamido-3-oxo-alkanoate intermediate. The process includes acylation of the oxime and reduction of the oxime ester group to an amido group. Following this, the keto and ester groups of the intermediate are reduced to form the 1,3 diol of the ceramide. The oxime acylation and the first reduction can be performed consecutively or simultaneously. The first reduction is preferably a catalytic hydrogenation, while the second reduction is ideally a borohydride reduction. Additionally, the invention introduces novel 2-alkanoylamido-3-oxo-alkanoates and 2-alkanoyloximino-3-oxo-alkanoates, which serve as useful intermediates for ceramide conversion.

Career Highlights

Brian J Hardinge is associated with Unilever Patent Holdings B.V., where he applies his expertise in the field of chemical innovations. His work has been instrumental in advancing the understanding and production of ceramides, which are vital in various applications, including cosmetics and pharmaceuticals.

Collaborations

Throughout his career, Brian has collaborated with notable colleagues such as Paul Nicholas Davey and Christopher P Newman. These collaborations have further enriched his research and development efforts in the field of ceramide preparation.

Conclusion

Brian J Hardinge's contributions to the field of ceramide preparation exemplify the impact of innovative thinking in chemistry. His patented process not only enhances production efficiency but also introduces valuable intermediates for further applications. His work continues to influence the industry positively.