Location History:
- Brookline, MA (US) (2001)
- Ann Arbor, MI (US) (2002)
Company Filing History:
2 out of 832,891 Years Active: 2001-2002
Title: Brian J Akerley: Innovator in Genetic Tools
Introduction
Brian J Akerley is a notable inventor based in Ann Arbor, MI (US). He has made significant contributions to the field of genetics, particularly in the development of transposable elements that serve as essential tools for genetic manipulation. With a total of 2 patents, Akerley's work is paving the way for advancements in genetic research.
Latest Patents
Akerley's latest patents include "Hyperactive mutants of Himar1 transposase and methods for using the same" and "Systematic identification of essential genes by in vitro transposon mutagenesis." The first patent focuses on the Himar1 element, which is a member of the mariner family of transposable elements. This element, isolated from the horn fly, has shown significant activity when expressed appropriately. Akerley devised a genetic screen to isolate hyperactive mutants of Himar1 transposase, enhancing overall transposition from 4 to 50-fold. This innovation is expected to improve the efficiency of various genetic manipulations, including random mutagenesis and transgenesis in a wide range of host cells.
The second patent presents a general system for identifying essential genes in organisms. This system is crucial for discovering novel target genes for antimicrobial compounds and for identifying genes that enhance cell growth or viability. Akerley's contributions in these areas are vital for advancing genetic research and applications.
Career Highlights
Throughout his career, Akerley has focused on the intersection of genetics and biotechnology. His innovative approaches have led to significant advancements in the understanding and application of transposable elements. His work is recognized for its potential to enhance genetic research and improve methodologies in various biological fields.
Collaborations
Akerley has collaborated with esteemed colleagues such as Eric J Rubin and John J Mekalanos. These collaborations have further enriched his research and contributed to the development of groundbreaking genetic tools.
Conclusion
Brian J Akerley's work in the field of genetics, particularly through his patents, showcases his innovative spirit and dedication to advancing scientific knowledge. His contributions are instrumental in enhancing the capabilities of genetic manipulation and research.