Brian H Kram

Title: Brian H. Kram: Innovating Cellular Containment Solutions

Introduction

Brian H. Kram is a notable inventor based in Flagstaff, Arizona, recognized for his contributions to the field of cellular containment and respiratory aids. With a total of two patents to his name, Kram has demonstrated a commitment to advancing technologies that improve the efficiency and effectiveness of cellular and medical applications.

Latest Patents

Kram's latest patents showcase innovative methodologies that address critical challenges in cell containment and respiration. One of his significant inventions is a method for closing a cell containment device with a wet seal. This method involves wetting a portion of a permeable polymeric membrane, such as a tubular membrane, with a liquid, such as a cell suspension or drug formulation. By applying heat to the wetted thermoplastic polymer, a "wet seal" closure is formed, ensuring a cell-tight closure as the polymer cools. This technique is particularly noteworthy as it allows for the direct implantation of the containment device into recipients in need of the treatment provided by its contents.

Another of Kram's innovative contributions focuses on respiratory aids. This invention is centered around materials that assist in the respiration of living cells within cell-containing systems. These materials create air-filled conduits or channels that facilitate gas exchange, such as oxygen and carbon dioxide, via diffusion. When integrated into an aqueous environment, such as cell-culture media or host tissue, this invention significantly enhances cellular respiration in cell-containing systems.

Career Highlights

Brian H. Kram is affiliated with Gore Enterprise Holdings, Inc., a company renowned for its dedication to innovation in medical technologies. His work in this esteemed organization has allowed him to bring groundbreaking inventions to life, directly impacting the fields of cellular therapy and medical device technology.

Collaborations

Throughout his career, Kram has collaborated with several accomplished colleagues, including Stanley L. Mish and Michael J. Muehlbauer. These partnerships have played a vital role in enhancing the quality and impact of the innovations developed within their projects.

Conclusion

Brian H. Kram stands out as a prominent inventor, contributing valuable advancements in cellular containment and respiratory technologies. Through his innovative patents and collaborations, he continues to push the boundaries of what is possible in the field, ultimately benefiting the medical community and patients alike.