Company Filing History:
1 out of 41 
1 out of 192 
Years Active: 2007-2025
Title: Brian C Schaefer: Innovator in Cellular Biology
Introduction
Brian C Schaefer is a notable inventor based in Columbia, MD (US), recognized for his contributions to cellular biology. He holds 2 patents that focus on innovative methods for immortalizing mammalian cells and evaluating cellular activation.
Latest Patents
One of his latest patents is titled "Immortalization of splenic and peripheral blood macrophages using a multi-cistronic v-raf/v-myc lentivirus." This patent discloses vectors and methods for immortalizing mammalian cells through the co-expression of v-raf and v-myc proteins. The use of a replication-defective viral vector enhances safety, and the method is particularly useful for producing immortalized macrophages. The process involves contacting the vector with a monocyte, proliferatively growing the monocyte, and subsequently growing the monocytic cell on both solid and porous surfaces. Another significant patent is the "Method to identify regulators of cellular activation using Bcl10." This patent outlines methods for evaluating the activation of Bcl10 in response to stimuli and for identifying regulatory compounds that influence Bcl10-mediated signal transduction.
Career Highlights
Throughout his career, Brian has worked with esteemed organizations such as the National Jewish Medical and Research Center and the Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. His work has significantly advanced the understanding of cellular mechanisms and their applications in medical research.
Collaborations
Brian has collaborated with prominent scientists, including Philippa Marrack and John W Kappler, contributing to a rich exchange of ideas and innovations in the field of cellular biology.
Conclusion
Brian C Schaefer's innovative work in cellular biology, particularly in the areas of macrophage immortalization and cellular activation, showcases his significant contributions to science and medicine. His patents reflect a commitment to advancing research methodologies that can lead to breakthroughs in understanding cellular functions.