Location History:
- Rumson, NJ (US) (2010 - 2014)
- Philadelphia, PA (US) (2014)
Company Filing History:
4 out of 3,440 
4 out of 3,378 
4 out of 11 
Years Active: 2010-2014
Title: Innovations of Brian C Capell
Introduction
Brian C Capell is a notable inventor based in Rumson, NJ, who has made significant contributions to the field of medical research. He holds a total of four patents, focusing primarily on the treatment of laminopathies, cellular aging, and atherosclerosis. His work has the potential to impact the lives of many individuals suffering from these conditions.
Latest Patents
One of Capell's latest patents involves Farnesyltransferase inhibitors for the treatment of laminopathies, cellular aging, and atherosclerosis. The research highlights that although the mutant lamin A protein expressed in Hutchinson Gilford Progeria Syndrome (HGPS) can be farnesylated, it cannot be defarnesylated due to a mutation that deletes a crucial cleavage site. This results in the production of an aberrant farnesylated protein known as 'progerin,' which disrupts normal lamin A function. Farnesyltransferase inhibitors (FTIs) are designed to inhibit the formation of progerin, thereby decreasing the amount of aberrant protein and improving cellular effects caused by progerin expression. The treatment with FTIs is expected to enhance disease status in progeria and other laminopathies, as well as improve elements of atherosclerosis and aging in non-laminopathy individuals.
Career Highlights
Throughout his career, Brian C Capell has worked with prestigious organizations, including the National Institutes of Health, a component of the US Department of Health & Human Services, and the University of Michigan. His experience in these institutions has contributed to his expertise in the field of medical research and innovation.
Collaborations
Capell has collaborated with notable individuals in his field, including Leslie B Gordon and Francis S Collins. These collaborations have likely enriched his research and contributed to the advancements in his patented technologies.
Conclusion
Brian C Capell is a distinguished inventor whose work in developing Farnesyltransferase inhibitors holds promise for treating serious medical conditions. His contributions to the field of medical research are noteworthy and have the potential to improve the quality of life for many individuals.