Company Filing History:
Years Active: 2010
Title: Innovations of Brian Bahler in Cellular Polysaccharide Purification
Introduction
Brian Bahler is an accomplished inventor based in Apex, NC (US). He has made significant contributions to the field of cellular polysaccharide purification, holding 2 patents that showcase his innovative approaches.
Latest Patents
His latest patents include a process for reducing the protein content while preserving the capsular polysaccharide content in a complex cellularlysate broth prior to purification. This method utilizes pH reduction after cellular lysis, resulting in a purified polysaccharide that consistently meets protein specifications and achieves higher recovery yields during the purification process. Another notable invention provides improved methods for the reduction or removal of protein impurities from a complex cellularlysate or centrate comprising serotype 3 polysaccharides. This involves post-lysis heating or pH adjustment, where the lysate is heated to at least 60°C for a sufficient time to denature proteins, causing their aggregation and precipitation.
Career Highlights
Brian Bahler works at Wyeth, a company known for its advancements in pharmaceuticals and biotechnology. His work has been instrumental in developing methods that enhance the purification processes of polysaccharides, which are crucial in various medical applications.
Collaborations
He has collaborated with notable coworkers such as Tsu-shun Lee and Jason Arnold Lotvin, contributing to the innovative research and development in their field.
Conclusion
Brian Bahler's contributions to the field of cellular polysaccharide purification through his patents reflect his dedication to innovation and improvement in biotechnological processes. His work continues to influence advancements in the industry.