Company Filing History:
Years Active: 2021-2025
Title: Brent W. Ferguson: Innovator in Genomic Target Enrichment
Introduction
Brent W. Ferguson is a notable inventor based in Cedar Creek, TX (US). He has made significant contributions to the field of genomic research, particularly in the area of DNA sequencing. His innovative work has led to the development of methods that enhance the efficiency and specificity of genomic target enrichment.
Latest Patents
Brent W. Ferguson holds a patent for "Methods and compositions for genomic target enrichment and selective DNA sequencing." This patent describes a groundbreaking approach to capturing and isolating large double-stranded DNA fragments, ranging from 2,000 to 40,000 base pairs in size. The invention utilizes sequence-specific PNA hybridization probes to enrich a multiplicity of long DNA sequences from the genome of any eukaryote. The method involves the use of multiple PNA molecules with gamma-modified chiral backbones, which include a mixture of neutral and positive chemical groups. By employing two or more PNA probes with covalently bound haptens, such as biotin, the method targets each DNA domain of interest for capture, isolation, and subsequent sequencing analysis. Additionally, the methods enhance probe-DNA binding specificity through the use of single-strand binding proteins (SSB).
Career Highlights
Brent W. Ferguson is associated with Petaomics, Inc., where he continues to advance his research in genomic technologies. His work has positioned him as a key figure in the field, contributing to the understanding and manipulation of genetic material.
Collaborations
Brent has collaborated with notable individuals in his field, including Paul M. Lizardi. These collaborations have further enriched his research and innovation efforts.
Conclusion
Brent W. Ferguson's contributions to genomic target enrichment and selective DNA sequencing exemplify the impact of innovative thinking in scientific research. His patent and ongoing work at Petaomics, Inc. highlight the importance of advancements in genomic technologies.