Brent Atkinson

Title: Brent Atkinson: Innovator in Nucleic Acid Ligand Development

Introduction

Brent Atkinson is a notable inventor based in Boulder, CO (US). He has made significant contributions to the field of nucleic acid ligands, holding a total of 4 patents. His work focuses on innovative methods for obtaining nucleic acid ligands that can photocrosslink to target molecules associated with various disease states.

Latest Patents

Atkinson's latest patents include groundbreaking methods for the systematic evolution of ligands by exponential enrichment. One of his notable inventions involves photoselection of nucleic acid ligands, which provides methods to obtain nucleic acid ligands that photocrosslink to target molecules associated with a disease state. The methods presented are variations on the photoSELEX techniques, which are designed to enhance the identification of nucleic acid ligands.

In one method, a candidate mixture of photocrosslinkable nucleic acids is contacted with a biological substance from a source associated with a disease state. This process forms nucleic acid-target molecule complexes, which are then irradiated to create crosslinked complexes. The photocrosslinked complexes are separated from the remaining candidate mixture, allowing for the retention of nucleic acid ligands that specifically bind to the target molecule.

Another method described in his patents involves the use of enriched candidate mixtures obtained by contacting biological substances associated with disease states. This innovative approach allows for the identification of nucleic acid ligands with high specificity and affinity for target molecules.

Career Highlights

Brent Atkinson has worked with several prominent companies in the pharmaceutical and biotechnology sectors. Notable among these are Nexstar Pharmaceuticals, Inc. and Somalogic, Incorporated. His experience in these organizations has contributed to his expertise in the development of nucleic acid ligands and their applications in disease treatment.

Collaborations

Atkinson has collaborated with esteemed colleagues in his field, including Larry M Gold and Michael Willis. These partnerships have furthered his research and innovation in nucleic acid technology.

Conclusion

Brent Atkinson's contributions to the field of nucleic acid ligands are significant and impactful. His innovative methods and collaborations continue to advance the understanding and application of nucleic acids in medical science.