Brendan P Mowery

Title: Innovations in Lung Surfactant Research by Brendan P Mowery

Introduction

Brendan P Mowery is an accomplished inventor based in San Marcos, CA. He has made significant contributions to the field of synthetic lung surfactants, with a focus on developing innovative materials that mimic natural surfactant proteins. His work has the potential to enhance respiratory therapies and improve patient outcomes.

Latest Patents

Mowery holds 3 patents, with his latest innovations centered around nylon-3 co-polymers and synthetic lung surfactant compositions. These non-natural oligomers have shown promise as functional analogues of lung surfactant proteins B and C (SP-B and SP-C), which are essential for normal respiration. His research presents an alternative approach to SP-B mimicry, utilizing sequence-random copolymers that contain cationic and lipophilic subunits. The nylon-3 polymers he developed demonstrate promising in vitro surfactant activities in mixed lipid films. Data from pulsating bubble surfactometry indicate that these polymers achieve superior adsorptive and dynamic-cycling properties compared to discrete peptides designed to mimic SP-B. Furthermore, the attachment of an N-terminal octadecanoyl unit to the nylon-3 copolymers enhances their performance by reducing surface area compression, allowing for lower minimum surface tension.

Career Highlights

Throughout his career, Mowery has worked with notable organizations, including the Wisconsin Alumni Research Foundation and Northwestern University. His research has contributed to advancements in the understanding and application of synthetic surfactants in medical settings.

Collaborations

Mowery has collaborated with esteemed colleagues such as Samuel Helmer Gellman and Shannon S Stahl, further enriching his research endeavors and expanding the impact of his work.

Conclusion

Brendan P Mowery's innovative research in synthetic lung surfactants represents a significant advancement in respiratory therapy. His contributions to the field are paving the way for new treatments that could greatly benefit patients with respiratory conditions.