Brendan Keating

Title: Brendan Keating: Innovator in Transplant Diagnostics and Autoimmune Diseases

Introduction

Brendan Keating is a prominent inventor based in Philadelphia, PA, known for his significant contributions to the fields of transplant diagnostics and autoimmune diseases. With a total of three patents to his name, he has made remarkable strides in medical research and innovation.

Latest Patents

One of Brendan Keating's latest patents focuses on the use of micro-ribonucleic acid (miRNA) to diagnose transplant rejection and assess tolerance of immunosuppression therapy. This invention relates to the discovery that certain miRNA expression levels can serve as a diagnostic signature to predict transplant outcomes in recipients. The methods described in this patent include diagnosing acute cellular rejection (ACR) and predicting a subject's risk of developing ACR, as well as assessing the likelihood of successful immunosuppression therapy dosage adjustments.

Another significant patent involves methods for diagnosing autoimmune diseases. This disclosure introduces new genetic targets, diagnostic methods, and therapeutic regimens for various autoimmune disorders, including those affecting pediatric patients. The methods outlined provide a means to diagnose or determine susceptibility to autoimmune diseases and to establish treatment protocols based on genetic alterations in specific genes.

Career Highlights

Brendan Keating has worked with esteemed institutions such as The Children's Hospital of Philadelphia and the University of Pennsylvania. His work in these organizations has allowed him to collaborate with leading experts in the field and contribute to groundbreaking research.

Collaborations

Throughout his career, Brendan has collaborated with notable colleagues, including Hakon Hakonarson and Yun Rose Li. These partnerships have further enhanced his research and innovation efforts.

Conclusion

Brendan Keating's work in the realm of transplant diagnostics and autoimmune diseases exemplifies the impact of innovative research on medical science. His patents reflect a commitment to improving patient outcomes through advanced diagnostic methods and therapeutic strategies.