This inventor holds 1 USPTO granted patent. Top assignee: National University of Singapore. Active years: 1999.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 1999
Title: Innovations of Bow Ho in Recombinant Protein Production
Introduction
Bow Ho is an accomplished inventor based in Singapore, known for his significant contributions to the field of biotechnology. He has developed innovative methods for the expression of recombinant proteins, particularly focusing on Factor C derived from the species Carcinoscorpius rotundicauda. His work has implications for various applications in medical and pharmaceutical research.
Latest Patents
Bow Ho holds a patent for the "Expression of carcinoscorpius rotundicauda factor C in eukaryotes." This patent details the cloning of CrFC21 cDNA into mammalian vectors, specifically pCIneo and pCDNAI, which utilize the strong CMV promoter for effective expression in mammalian cell lines. The research demonstrates the successful transformation of various CrFC cDNA constructs into P. pastoris and S. cerevisiae, yielding full-length recombinant Factor C (rCrFC) protein of approximately 130 kDa, which is immunoreactive. The rCrFC is expressed in an intracellular, insoluble form, providing protection from premature digestion by host cell proteases. The protein can be solubilized and purified under pyrogen-free conditions, maintaining its biological functionality through established denaturation and renaturation protocols.
Career Highlights
Bow Ho is affiliated with the National University of Singapore, where he has been instrumental in advancing research in recombinant protein production. His innovative approaches have contributed to the understanding of protein expression and purification techniques, enhancing the potential for therapeutic applications.
Collaborations
Bow Ho collaborates with Jeak Ling Ding, working together to further their research in the field of biotechnology. Their combined expertise has led to advancements in the production and application of recombinant proteins.
Conclusion
Bow Ho's contributions to the field of biotechnology, particularly in the expression of recombinant proteins, highlight his innovative spirit and dedication to scientific advancement. His work continues to influence research and development in medical applications.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile